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Will rabeprazole interfere with other medicines I take?

Rabeprazole may interact with several other medicines. An especially important interaction is that of rabeprazole with the drugs delavirdine, erlotinib, nelfinavir and posaconazole. Delavirdine and nelfinavir are both used to treat HIV, the virus that causes AIDS. The amount in your bloodstream (the serum concentration) of delavirdine or of nelfinavir is greatly decreased when rabeprazole is also being used. So, the combination of rabeprazole with either of these HIV drugs should be avoided entirely. Erlotinib is used as part of chemotherapy to treat lung cancer. The concentration of erlotinib is also very much reduced when taken with rabeprazole, so combining erlotinib with rabeprazole is not a safe option. Finally, posaconazole is an anti-fungal medicine used to treat certain infections in people whose immune systems are very weak. Combining this medicine with rabeprazole reduces the amount of posaconazole in the blood, which could be very dangerous. Several other drugs, including a medicine used to treat attention deficit-hyperactivity disorder (ADHD), called dexmethylphenidate, can also interact with rabeprazole. Always be sure to give your doctor a complete list of all the drugs you are taking, including over-the-counter medicines and dietary supplements. This will reduce the risk of your having a dangerous drug interaction.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.