Can Prozac interact with other medications or foods?

The antidepressant Prozac (fluoxetine) isn't known to interact with any foods, although alcohol can make the drowsiness often caused by Prozac worse, so it's best not to drink while taking it.

Prozac may interact with a number of drugs and supplements, including:

• blood thinners or anticoagulants
• other antidepressants or antipsychotics
• certain anti-arrhythmic drugs
• diuretics
• insulin or oral diabetes medications
• medications to treat Parkinson's disease
• migraine or seizure medications
• painkillers (aspirin, ibuprofen, naproxen)
• sedatives, tranquilizers or sleeping pills
• St. John's wort
• tryptophan

This is not a complete list, so be sure to tell your doctor about any medications and supplements you take before starting Prozac.