Can Prozac interact with other medications or foods?

The antidepressant Prozac (fluoxetine) isn't known to interact with any foods, although alcohol can make the drowsiness often caused by Prozac worse, so it's best not to drink while taking it.

Prozac may interact with a number of drugs and supplements, including:
  • blood thinners or anticoagulants
  • other antidepressants or antipsychotics
  • certain anti-arrhythmic drugs
  • diuretics
  • insulin or oral diabetes medications
  • medications to treat Parkinson's disease
  • migraine or seizure medications
  • painkillers (aspirin, ibuprofen, naproxen)
  • sedatives, tranquilizers or sleeping pills
  • St. John's wort
  • tryptophan
This is not a complete list, so be sure to tell your doctor about any medications and supplements you take before starting Prozac.

Continue Learning about Fluoxetine

Can fluoxetine treat other conditions?
Stacy Wiegman, PharmDStacy Wiegman, PharmD
Yes. Fluoxetine has been used to treat disorders other than depression. Before taking fluoxetine...
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Should pregnant women take fluoxetine?
Stacy Wiegman, PharmDStacy Wiegman, PharmD
No. If you’re pregnant or planning to be, don’t take fluoxetine. This medicine is a selective se...
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What should I avoid while taking fluoxetine?
Stacy Wiegman, PharmDStacy Wiegman, PharmD
Avoid taking a monoamine oxidase inhibitor (MAOI), St. John's wort, or other drugs that might intera...
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What happens if I miss a dose of fluoxetine?
Stacy Wiegman, PharmDStacy Wiegman, PharmD
Fluoxetine works best if taken at regular intervals as prescribed by your doctor. If you miss a dose...
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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.