Can fluoxetine be used to treat premature ejaculation?

Although no form of fluoxetine is specifically approved to treat premature ejaculation, antidepressants have been found to help because they sometimes have the effect of delaying orgasm. Fluoxetine would be used in conjunction with other forms of therapy to treat premature ejaculation. Using fluoxetine to treat premature ejaculation would be considered an "off-label" but legal treatment. If these treatments do not work, the doctor may prescribe a stronger antidepressant.

Ian Kerner, PhD
Sexual Health

Prozac (fluoxetine) can help to treat premature ejaculation (PE). Prozac is prescribed “off label” by physicians, which means that the medication is typically used to treat another condition. Below is a brief list of some things you may need to know about the drug:

• Type: selective serotonin reuptake inhibitor

• Typical dose: 10 to 20 milligrams per day

• Side effects: nausea, headache, insomnia, nervousness, dizziness

• What to expect: may take 3 to 6 weeks to see benefits for PE; must be taken every day

• Should be used with caution by men with diabetes or a history of seizures

Notes: May interact with the anti-seizure drug phenobarbital, warfarin (Coumadin), lithium, sedatives, alcohol, and some other antidepressants


The Good in Bed Guide to Overcoming Premature Ejaculation

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The Good in Bed Guide to Overcoming Premature Ejaculation

From the New York Times best-selling author of She Comes First arrives the definitive guide to managing premature ejaculation – a book that could save your sex life!Do you suffer from PE? Are you...

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.