What are the side effects of follitropin alfa?

Common side effects of follitropin alfa use are:

  • discomfort at the site of injection
  • breast growth or pain
  • acne
  • sinus infection
  • headache
  • fatigue
  • and upset stomach

There is also risk for developing severe side effects. These include:

  • an allergic reaction which may cause hives
  • rash
  • itching
  • trouble breathing
  • swelling of the face, lips, tongue, or throat

Other severe side effects include:

  • pain, redness, warmth, tingling, or numbness of an arm or leg (which can indicate formation of a blood clot)
  • abnormal vaginal bleeding
  • unusual vaginal itching, discharge, or odor
  • confusion, severe dizziness, or a severe headache
  • vision changes
  • calf pain or tenderness
  • severe pelvic or back pain
  • fever
  • difficulty breathing, or severe and persistent shortness of breath
  • chest pain
  • confusion
  • one-sided weakness
  • or slurred speech

If you experience any severe side effects, seek medical attention right away.

Additionally, about 5 percent of patients who use follicle stimulating hormone drugs like follitropin alfa may develop ovarian hyperstimulation syndrome (OHSS), particularly after the first cycle of use. Symptoms of this potentially fatal syndrome include severe pelvic pain, abdominal pain and swelling, swelling of the hands or legs, weight gain, low urine output, diarrhea, shortness of breath, and nausea or vomiting. Tell your doctor immediately or seek emergency medical help if you have any of these symptoms.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.