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What are the side effects of follitropin alfa injection?

Common side effects of follitropin alfa injection use are:

  • discomfort, bruising, or pain at the injection site
  • breast pain
  • sinus inflammation
  • headache
  • sore throat
  • stuffy nose
  • stomach pain or nausea

Other side effects may include:

  • fever or chills
  • ovarian enlargement that causes abdominal or pelvic pain, pressure, tenderness, or swelling
  • muscle or joint weakness or aching
  • dizziness
  • nausea, vomiting, diarrhea, or gas
  • hair loss
  • rapid pulse or heart rate
  • spotting or menstrual changes
  • dry skin or rash

There is risk for developing severe side effects. These include:

  • an allergic reaction which may cause hives, rash, itching, trouble breathing, or swelling of the face, lips, tongue, or throat
  • pain, redness, warmth, tingling, or numbness of an arm or leg (which can indicate formation of a blood clot)
  • one-sided weakness
  • abnormal vaginal bleeding
  • unusual vaginal itching, discharge, or odor
  • decreased urination
  • diarrhea
  • vision changes
  • vomiting
  • confusion, severe dizziness, or a severe headache
  • calf pain or tenderness
  • chest pain
  • severe or persistent stomach pain, bloating, or upset
  • severe pelvic or back pain
  • sudden and unexplained weight gain
  • fever
  • difficulty breathing or severe and persistent shortness of breath
  • confusion
  • slurred speech

If you experience any severe side effects, seek medical attention right away.

Additionally, about 5 percent of patients who use follicle stimulating hormone drugs like follitropin alfa injection may develop ovarian hyperstimulation syndrome (OHSS), particularly after the first cycle of use. Symptoms of this potentially fatal syndrome include severe pelvic pain, abdominal pain and swelling, swelling of the hands or legs, weight gain, low urine output, diarrhea, shortness of breath, and nausea or vomiting. Tell your doctor immediately or seek emergency medical help if you have any of these symptoms. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.