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What are fibrates?

Donna Hill Howes, RN
Family Practitioner

Fibrates limit the production of triglycerides by the liver. They also help remove triglycerides and LDL cholesterol from the blood and increase the production of HDL cholesterol.

Several fibrate drugs are available in the US. These include fenofibrate (Antara, Fenoglide, Lipofen, Tricor, Triglide), fenofibric acid (Fibricor, Trilipix), and gemfibrozil (Lopid).

The use of non-statin drugs to reduce cardiovascular risk has been called into question. A large study found that fibrates did not reduce the risk of stroke, heart attack, or death in people already taking a statin. (Fibrates did reduce the risk of non-fatal heart attack in people who were not taking a statin.) Further, United Kingdom guidelines (NICE 2014) state that fibrates offer no benefit and should not be routinely offered.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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