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How do fibrates interact with other medications?

Donna Hill Howes, RN
Family Practitioner

If you are taking a QTc interval prolonging medication, fibrates can lead to serious side effects and should be avoided.

If you are taking repaglinide, you should not take gemfibrozil.

If you are taking bexarotene, enzalutamide, irinotecan, pirfenidone, or tizanidine, gemfibrozil can lead to side effects and should be avoided.

If you are taking colchicine, cyclosporine, or raltegravir, a fibrate may not be a good option for you.

If you are taking ezetimibe, gemfibrozil can lead to side effects and should be avoided. Other fibrates may also not be good options for you.

If you are taking simvastatin, you should not take gemfibrozil. If you are taking another statin, gemfibrozil can lead to side effects and should be avoided if possible.

If you are taking tacrolimus, fenofibrate may not be a good option for you.

If you are taking Viekira (a combination of ombitasvir, paritaprevir, ritonavir, and dasabuvir), gemfibrozil can lead to side effects and should be avoided.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.