Who should not use estradiol acetate?

Do not use estradiol acetate if the following apply:

  • allergic reactions to the active and inactive ingredients
  • cancers of the breast or uterus, any cancer that would be stimulated by hormones
  • history of blood clots
  • liver disease
  • pregnant or breastfeeding
  • unusual vaginal bleeding

If the following apply, your doctor may need to conduct tests or change your dose:

  • asthma                                                     
  • diabetes
  • chest pains
  • depression
  • endometriosis
  • gallbladder disease
  • heart attack
  • high blood pressure
  • high cholesterol
  • hysterectomy (removal of uterus)
  • kidney disease
  • family history of blood clots
  • liver disease
  • low calcium levels in your blood
  • lupus
  • migraines
  • previous jaundice ( yellowing of skin or eyes)
  • porphyria
  • seizure disorder
  • stroke
  • underactive thyroid
  • uterine fibroids


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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.