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What are the side effects of estropipate?

Common and less serious side effects of using estropipate include:
  • nausea, vomiting, loss of appetite, weight fluctuation
  • abnormal hair growth or hair loss
  • swollen or tender breasts
  • acne or skin color changes
  • inability to tolerate contact lenses
  • inability to tolerate carbohydrates
  • flushing
  • decreased sex drive, impotence, or difficulty having an orgasm
  • headaches, migraine headaches, dizziness, lightheadedness
  • vaginal pain, dryness, discomfort, or infection
  • swelling
  • depression
  • stomach bloating or upset
  • cramps, changes in your menstrual periods, breakthrough bleeding
Seek medical attention if you experience severe or persistent side effects.

More serious side effects of using estropipate are:
  • an allergic reaction to the drug that can include hives, rash, itching, a tight chest, difficulty breathing, or swelling of the face, lips, mouth, or tongue
  • chest pain or heavy feeling, pain spreading to the arm or shoulder
  • calf pain
  • pain or swelling in your lower leg, hands, or feet
  • a swollen, painful, or tender stomach
  • nausea, vomiting, sweating, general ill feeling
  • sudden numbness or weakness, especially on one side of the body
  • sudden or severe headache, confusion, dizziness,
  • fainting, problems with balance
  • mental or mood changes like memory problems or severe depression
  • vision changes like contact lenses no longer fitting or loss of vision
  • changes in speech
  • breast lumps
  • abnormal vaginal bleeding such as breakthrough bleeding,
  • potting, or prolonged bleeding
  • unusual vaginal discharge, odor, or itching
  • jaundice (yellowing of the skin or eyes) or
  • a lump in your breast
  • coughing up blood
  • sudden shortness of breath
  • jaundice (yellowing of the skin or eyes)
Contact your doctor right away, or call 911 for life threatening symptoms, if you experience any of these serious side effects.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.