What should I know about Natazia before taking it?

Before taking Natazia (a combination of the hormones estradiol valerate and estradiol valerate/dienogest), you should be aware of the following:

  • Birth control pills like Natazia are as effective in preventing pregnancy as birth control patches and vaginal rings; more effective than condoms, diaphragms, and spermicide; and less effective than implants, injections, and intrauterine devices.
  • The most serious risk associated with Natazia is increased risk of blood clots, which can affect the brain, heart, lungs, limbs, or sight. Women who are over 35, obese, or who smoke have a greater risk for serious events related to blood clots, including heart attack or stroke.
  • If you are nursing, Natazia may pass into breast milk and may decrease the amount of milk you produce.

Some less common risks from taking Natazia are disproportionately high in people with certain pre-existing conditions:

  • Diabetics or pre-diabetics may see an increase in blood sugar levels, especially at higher doses.
  • Women with a history of depression, may experience a return and worsening of symptoms.
  • Those with liver disease may suffer increased risk of liver disease or tumors.
  • Women with already high triglyceride levels or a family history of lipid conditions will have a higher risk of pancreatitis.
  • Those with angioedema may experience worsening of symptoms.

It is not advisable to use Natazia if you are prone to migraine headaches, but if you do, stop taking this medication if migraines occur more frequently or become more severe.


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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.