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What are the risks of using Estrace vaginal cream?

Estrace vaginal cream contains the hormone estradiol, a form of estrogen. Using medications that contain estrogen increases your risk for developing endometrial cancer, which is cancer of the uterus (or womb). This risk appears to be greatest in women who use estrogens for more than one year. If you use Estrace vaginal cream, your doctor may prescribe another type of medication known as a progestin to reduce the risk for endometrial cancer. Studies show that using estrogens with or without progestin may increase your risk for the following:
  • heart attacks
  • strokes
  • blood clots in the lungs, legs, or elsewhere
  • breast cancer
  • ovarian cancer
  • gallbladder disease
Also, using estrogens with progestin may increase your risk of dementia, or loss of memory and other mental functions. Talk to your doctor and weigh the benefits of using Estrace vaginal cream against these known risks.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.