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What are the side effects of vaginal estrogen creams or suppositories?

Donna Hill Howes, RN
Family Practitioner

Side effects may include headaches, nausea, breast tenderness, a blotchy skin discoloration, weight changes, depression, fluid retention, enlargement of uterine fibroids, and abnormal uterine bleeding.

Estrogen therapy has been linked to breast, ovarian, endometrial, and other cancers. It is also associated with blood clots, heart attacks, and strokes. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.