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What should I know before taking a PDE-5 inhibitor?

Donna Hill Howes, RN
Family Practitioner

If you take a PDE-5 inhibitor, you should avoid grapefruit juice.

If you have a bleeding disorder, sildenafil and vardenafil may not be good options for you.

If you have cardiovascular disease, a PDE-5 inhibitor may not be a good option for you.

If you have recently had a stroke, PDE-5 inhibitors can lead to side effects and should be avoided.

If you have high blood pressure, a PDE-5 inhibitor can lead to side effects and should be avoided.

If you have severe liver impairment, tadalafil can lead to side effects and should be avoided. Other PDE-5 inhibitors may also not be good options for you.

If you have peptic ulcer, sildenafil and vardenafil may not be good options for you.

If you have hereditary degenerative retinal disorders, such as retinitis pigmentosa, a PDE-5 inhibitor can lead to side effects and should be avoided.

If you have low blood pressure, you should not take a PDE-5 inhibitor.

If you have an abnormally shaped penis, a PDE-5 inhibitor may not be a good option for you.

If you use nitrite inhalants, you should not take a PDE-5 inhibitor. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.