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What other drugs interact with PDE-5 inhibitors?

Donna Hill Howes, RN
Family Practitioner

If you are taking alprostadil, conivaptan, fusidic acid, idelalisib, or riociguat, PDE-5 inhibitors can lead to side effects and should be avoided.

If you are taking an azole antifungal drug or a strong CYP3A4 inhibitor, avanafil can lead to side effects and should be avoided.

If you are taking boceprevir, pimozide, or telaprevir, sildenafil can lead to side effects and should be avoided.

If you are taking a nitrate drug, you should not take a PDE-5 inhibitor.

If you are taking a QTc interval prolonging medication, vardenafil can lead to side effects and should be avoided.

If you are taking tipranavir or an alpha-1 adrenergic blocking agent, tadalafil can lead to side effects and should be avoided. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.