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What drugs are used for penile injections for erectile dysfunction (ED)?

Marc B. Garnick, MD
Hematology & Oncology
There are several drugs used in penile injections for erectile dysfunction (ED), all of which work by relaxing the smooth muscle tissue of the penis, permitting adequate blood flow for an erection. The only injectable drug specifically approved for ED is alprostadil (Caverject, Edex). However, phentolamine (Regitine), which was approved for another use, is also effective for ED, as are drug combinations such as papaverine, phentolamine, and prostaglandin.

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