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How effective are PDE-5 inhibitors?

Donna Hill Howes, RN
Family Practitioner

An analysis of 82 studies found that PDE-5 inhibitors were effective in 20% to 47% of men. Effectiveness was different for each drug depending on dosage, but highest dosages were not always the most effective. In general, sildenafil was the most effective and avanafil the least effective.

In two studies, tadalafil taken once daily provided treatment satisfaction comparable to PDE-5 inhibitors taken on demand. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.