Who should not take rasburicase?

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You should not take rasburicase (brand name Elitek), a medication used to treat high levels of uric acid, if any of the following apply to you:
  • You have had a severe allergic reaction to Elitek or to ingredients used in Elitek.
  • You have previously responded to Elitek with a blood cell reaction called hemolytic anemia or methemoglobinemia.
  • You have a genetic disorder called glucose-6-phosphatase dehydrogenase (G6PD) deficiency. A G6PD deficiency can cause a hemolytic reaction to rasburicase -- which means that the red blood cells in your body would begin to break down more quickly than normal, leading to symptoms such as paleness, yellow skin or eyes (jaundice) and dark-colored urine. This can be serious.