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How does secondary hyperparathyroidism progress?

As secondary hyperparathyroidism progresses, the parathyroid glands no longer respond normally to calcium and Vitamin D. During early secondary hyperparathyroidism, the blood calcium levels are normal or low, but the PTH level is high. As the disease gets worse, some of the treatments for the kidney disease (Vitamin D and calcium-containing phosphate binders) may eventually lead to abnormally high levels of calcium in the blood. High PTH levels can lead to weakening of the bones, calciphylaxis (when calcium forms clumps in the skin and leads to ulcers and potentially death of surrounding tissue), cardiovascular complications, abnormal fat and sugar metabolism, itching (pruritis), and low blood counts (anemia).

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.