Does HRT cause heart or cerebrovascular disease?

Carolyn  Thomas

The Women's Health Initiative, a major independent 15-year research program begun in 1991, reported in 2002 that the demonstrated risks of hormone replacement therapy (HRT) outweighed benefits in asymptomatic women. Increased risks for stroke, deep vein thrombosis, dementia, incontinence and breast cancer were so clearly demonstrated, in fact, that the HRT study was stopped early.

These findings on the use of estrogen-progestin and estrogen-only HRT drugs were alarming, according to Dr. Adriane Fugh-Berman of Georgetown University Medical Center. In a more recent study* examining 340 medical journal articles written about HRT, she and her research team examined the admitted drug industry financial conflicts of interests disclosed by authors of HRT-friendly medical journal articles; it was published in March 2011 in the journal, Public Library of Science Medicine.

* Fugh-Berman A, McDonald CP, Bell AM, Bethards EC, Scialli AR (2011) Promotional Tone in Reviews of Menopausal Hormone Therapy After the Women’s Health Initiative: An Analysis of Published Articles. PLoS Med 8(3): e1000425. doi:10.1371/journal.pmed.1000425

Continue Learning about Endocrine System

Endocrine System

Your endocrine system works with your nervous system to control important bodily functions. The endocrine systems responsibilities include regulating growth, sexual development and function, metabolism and mood. The endocrine syst...

em also helps give your body the energy it needs to function properly. Endocrine glands secrete hormones into the bloodstream. Hormones are considered chemical messengers, coordinating your body by transferring information from one set of cells to another. Your endocrine system health can be affected by hormone imbalances resulting from impaired glands. A hormone imbalance can cause problems with bodily growth, sexual development, metabolism and other bodily functions. Endocrine system diseases or conditions include diabetes, growth disorders and osteoporosis.

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.