How can Clomiphene help me with infertility?

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Jeffrey S. Klein, MD
Diagnostic Radiology
Clomiphene Citrate, or "Clomid," is often referred to as the "fertility pill." It is used to treat infertile women who have an ovulation problem. It works by helping the pituitary gland (located at the base of the brain) improve the stimulation of developing follicles (eggs) in the ovaries. Clomiphene is most often prescribed to patients who have been found to have an abnormality with their cycle, though combined with intrauterine insemination, it may be useful in the treatment of unexplained infertility.
Clomiphene is usually prescribed for five days each cycle, usually beginning on day three or five. Of all women treated with Clomiphene 60% to 80% will ovulate normally. Nearly 10% of women treated with Clomiphene may experience mild side effects, including hot flashes, blurred vision, nausea, bloating sensation, and headaches. Serious side effects are rarely seen with Clomiphene therapy. The frequency of twins occurring in women who conceive while taking Clomiphene has been reported to be as high as 10%. New studies suggest that long-term use of Clomiphene for more than 12 cycles may place patients at an increased risk of developing ovarian cancer.