What is the likelihood of having a child with Down syndrome?

The likelihood of having a child with Down syndrome is about 1 in 700. The risk is higher if the mother is over 35, and gets higher with increasing maternal age.
Down syndrome occurs in people of all races and economic levels, although older women have an increased chance of having a child with Down syndrome. A 35-year-old woman has about a one in 350 chance of conceiving a child with Down syndrome; this chance increases gradually to one in 100 by age 40. At age 45 the incidence becomes approximately one in 30.

This content originally appeared on the National Down Syndrome Society website.

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