What side effects does Spironolactone (Aldactone) cause?

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Seek emergency medical attention if you experience signs of an allergic reaction while taking spironolactone such as hives, difficulty breathing, or swelling of the face, tongue, lips, or throat.

Call your doctor if you have any of the following serious side effects of spironolactone: tremors or confusion; a numb or tingly feeling in hands or feet; muscle pain or weakness; extreme fatigue and fainting; inability to move arms or legs; unusual bruising or bleeding; bloody stools; vomiting blood; less urination; loss of appetite or upset stomach; altered skin pigmentation, especially if it is gray or yellow in color (jaundice); blurry vision; or an uneven or increased heart rate. Some side effects of spironolactone are more mild, and do not require medical attention. However, you should call your doctor if the following side effects worsen or persist for an extended period of time: gas with an upset stomach; diarrhea or vomiting; headache or dizziness; dry mouth or increased thirst; a mild skin rash, and drowsiness or restlessness.

Spironolactone may also affect hormones, which may cause side effects such as: irregular menstrual cycle in women; vaginal bleeding in postmenopausal women; enlarged or tender breasts in women or men; difficulty achieving or maintaining an erection in men; growth of bodily hair, and a deepening of the voice.