What are the most common side effects of hydrochlorothiazide?

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The most common side effects of taking hydrochlorothiazide are diarrhea, constipation, stomach ache, dizziness, and/or blurred vision. Talk to your doctor if any of these common side effects become bothersome or grow more persistent, as your doctor may need to adjust your hydrochlorothiazide dosage. If you develop one or more of the following serious side effects, call your doctor right away:
  • Persistent thirst
  • Nausea, vomiting
  • Irregular heartbeat
  • Muscle pain or weakness
  • Numbness or tingling of skin in any part of your body
  • Rash, redness of the skin
  • Persistent fever
  • Change in stool or urine color
  • Jaundice
  • Change in appetite (loss of appetite)
If you experience serious allergic reaction symptoms (hives, difficult breathing, swelling of the lips, tongue, face, or throat), call 911 for emergency medical attention.

While taking hydrochlorothiazide for your edema or high blood pressure, do not start a new medication without first talking to your doctor. Other medications can increase the risk for more serious hydrochlorothiazide side effects.