What should I know about ethacrynic acid before taking it?

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Do not use this medication if you cannot urinate, have had watery diarrhea recently, have kidney disease, liver disease, or gout. Because you will urinate frequently on this medication, you should take precautions against dehydration and problems with your salt or potassium levels. To make sure you react in a healthy way to the medication, your doctor will frequently check your blood, weight, and liver and kidney function.

Ethacrynic acid can make you drowsy, so see how this affects you before operating a car or machinery. Avoid alcohol to limit the drowsy effect. Other drugs that you should avoid include amikacin, blood pressure medicines, blood thinners, cancer medicine, cephalosporin, digoxin, gentamicin, lithium, netilmicin, nonsteroidal anti-inflammatory drugs (NSAIDs), other diuretics, salicylates, steroids (prednisone and others), streptomycin, and tobramycin. These medications can interact with ethacrynic acid.

Ethacrynic acid should not be dangerous to use during pregnancy, but tell your doctor if you are or are thinking of becoming pregnant while taking ethacrynic acid. The effects of ethacrynic acid on a breastfeeding baby are not known, so talk to your doctor about the possible risks.