Does oretic interact with other foods and medications?

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Drinking alcohol while taking Oretic (hydrochlorothiazide) may increase the side effects of this medication. Certain over-the-counter medications, such as cold medicine and pain medicine, can make you lightheaded if you take Oretic. Medications that can interact with Oretic include lithium, digoxin, cholestyramine, steroids, blood pressure medications, nonsteroidal anti-inflammatory drugs (NSAIDs), insulin, and oral diabetes medications.