How does spironolactone treat nephrotic syndrome?

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As a diuretic, spironolactone helps the kidneys excrete water and sodium chloride. Spironolactone and other diuretics can treat nephrotic syndrome by increasing the amount of urine the kidneys produce. This also reduces the edema, or fluid retention, caused by nephrotic syndrome.

It is a kidney disorder that causes an excessive amount of protein to be excreted in the urine. This leaves a higher than normal ratio of water to protein in the blood, such that the water leaks into body tissues causing one of the signs of nephrotic syndrome: edema, or water retention, around the eyes and in the ankles and feet. The syndrome is usually caused by damage to the clusters of tiny blood vessels in the kidney (called glomeruli) that normally filter waste products from the blood and keep proteins in the blood.