Does spironolactone interact with other medications or foods?

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Spironolactone interacts with high blood pressure medications, such as eplerenone, and other medications containing spironolactone, such as Aldactazide or similar diuretics that affect potassium levels (amiloride, triamterene).

Spironolactone may also interact with the following medications:
  • digoxen
  • blood pressure medications, including angiotensin-converting enzyme (ACE) inhibitors
  • lithium (Eskalith, Lithobid)
  • nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, naproxen, or diclofenac
  • norepinephrine
  • steroids, such as prednisone or dexamethasone
  • drugs that relax skeletal muscles
Tell your doctor if you take any of these medications, so you can discuss if spironolactone is safe for you.

Spironolactone may interact with drugs that are not on this list, so tell your doctor if you take any over-the-counter drugs, dietary supplements (especially potassium supplements), vitamins or minerals, and herbal supplements.

Tell your doctor if you use alcohol, nicotine, or illegal drugs, as these may also interact with spironolactone.

Diet plays an important role in the effectiveness and safety of spironolactone. During treatment, do not eat a diet high in salt or salt substitutes.

Avoid excess sodium and potassium intake while you are taking spironolactone.

Follow your doctor's advice on how to stay hydrated during treatment, as too much or too little fluid in your system can be dangerous.