Can Microzide interact with other medications or foods?

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Microzide (hydrochlorothiazide), a diuretic prescribed to lower high blood pressure or reduce fluid retention, can interact with several medications, both prescription and over-the-counter.

Among other drugs, medications that can interact with Microzide include:
  • other high blood pressure drugs
  • nonsteroidal anti-inflammatory drugs, such as ibuprofen (Motrin) and naproxen (Aleve)
  • corticosteroids, such as prednisone
  • lithium
  • diabetes drugs
  • the gout drug probenecid (Benemid)
  • some vitamins
You may be able to take Microzide and one or more of these medications, but your doctor may need to adjust your dose of one of the drugs and monitor you for reactions. If you take cholestyramine or colestipol to lower your cholesterol, take it at least one hour before or after taking Microzide.

There are some general cautions about your diet while you're on Microzide. If you drink alcohol, you should be aware that Microzide can make you drowsy, and alcoholic beverages can enhance that effect. Because Microzide may lower your potassium level, your doctor may put you on a low-sodium, high-potassium diet; if so, follow it carefully.