Will amiloride and hydrochlorothiazide interact with other drugs or foods?

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Yes, amiloride-hydrochlorothiazide (HCTZ) can interact with several medications, including lithium; steroids; cyclosporine (Sandimmune, Gengraf, Neoral); blood thinners, such as warfarin (Coumadin); digoxin (Lanoxin); angiotensin II antagonist drugs (often called 'sartans'), such as candesartan (Atacand), valsartan (Diovan) and others; tacrolimus (Prograf); insulin; diabetes medications; ACE inhibitors, such as enalapril (Vasotec), benazepril (Lotensin), ramipril (Altace) and others; and nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, ibuprofen (Advil, Motrin), aspirin, naproxen (Naprosyn, Aleve) and others. The prescribing doctor needs to know about all other new medications before starting them. In addition, some side effects of amiloride-HCTZ can be exacerbated by alcohol. Salt substitutes and low-sodium milk products that have potassium should be avoided, as they can lead to high levels of potassium. A diet that is high in salt should also be avoided, because it can cause water retention and make amiloride-HCTZ less effective.