Will amiloride and hydrochlorothiazide interact with other drugs or foods?

Yes, amiloride-hydrochlorothiazide (HCTZ) can interact with several medications, including lithium; steroids; cyclosporine (Sandimmune, Gengraf, Neoral); blood thinners, such as warfarin (Coumadin); digoxin (Lanoxin); angiotensin II antagonist drugs (often called 'sartans'), such as candesartan (Atacand), valsartan (Diovan) and others; tacrolimus (Prograf); insulin; diabetes medications; ACE inhibitors, such as enalapril (Vasotec), benazepril (Lotensin), ramipril (Altace) and others; and nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, ibuprofen (Advil, Motrin), aspirin, naproxen (Naprosyn, Aleve) and others. The prescribing doctor needs to know about all other new medications before starting them. In addition, some side effects of amiloride-HCTZ can be exacerbated by alcohol. Salt substitutes and low-sodium milk products that have potassium should be avoided, as they can lead to high levels of potassium. A diet that is high in salt should also be avoided, because it can cause water retention and make amiloride-HCTZ less effective.

Continue Learning about Diuretic

How effective are loop diuretics for heart failure management?
Donna Hill Howes, RNDonna Hill Howes, RN
Loop diuretics can reduce shortness of breath, improve physical stamina, and reduce leg or ankle swe...
More Answers
What conditions do diuretics treat?
HCA VirginiaHCA Virginia
The most common conditions diuretics treat are high blood pressure and congestive heart failure. Les...
More Answers
Are diuretic drugs safe?
Nicole BasileNicole Basile
With the proper dosing and oversight of a physician, diuretic medications can be used safely to trea...
More Answers
Do loop diuretics interact with any other medications?
Donna Hill Howes, RNDonna Hill Howes, RN
If you are taking an aminoglycoside, loop diuretics can lead to side effects and should be avoided. ...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.