What should I know about chlorthalidone before taking it?


Chlorthalidone should not be used by individuals unable to urinate. Do not use this medication if you are allergic to diuretics. Alcoholic beverages should be avoided, as they may increase the side effects of chlorthalidone. Drink the amount and type of liquids recommended by your doctor, and avoid becoming overheated or dehydrated during physical activity in hot weather. Inform your doctor if you have any of the following health conditions, which may become worse when taking chlorthalidone:

  • allergy to sulfa drugs
  • asthma
  • diabetes
  • gout
  • hypercalcemia
  • hyperuricemia
  • hypochloremia
  • hypokalemia
  • hypomagnesemia
  • hyponatremia
  • hypophosphatemia
  • systemic lupus erythematosis

The side effects of chlorthalidone may be intensified in individuals with liver or kidney disease, because the medication is not removed from the body as quickly. Certain other medications may negatively interact with chlorthalidone. Chlorthalidone can cause drowsiness and some other medications may add to this effect, including:

  • medicines for colds and allergies
  • sedatives
  • muscle relaxants
  • narcotic pain relief medication
  • sleeping pills
  • lithium
  • digoxin
  • steroids
  • other medications for high blood pressure
  • insulin
  • oral diabetes medications
  • medications for depression or anxiety
  • seizure medications

Inform your doctor about all other prescription medications, over-the-counter drugs, vitamins, supplements, and herbs you are taking.