What should I know about gadoversetamide injection before receiving it?

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Gadoversetamide injection should not be taken by people with renal insufficiency (limited kidney function), including renal insufficiency during hospitalization for liver transplant or renal insufficiency associated with hepatorenal syndrome (a serious disorder of liver and kidneys at the same time). These conditions put you at risk for a possibly fatal condition called nephrogenic systemic fibrosis (NSF). Even if you do not have any known kidney disorders, your doctor should screen you for them before administering gadoversetamide. You also should avoid gadoversetamide if you have a history of allergy to it or related drugs. People with histories of the following medical conditions should not take gadoversetamide injection except on recommendation of their doctor:

  • kidney disease
  • heart disease
  • seizures
  • respiratory allergies
  • sickle cell or hemolytic anemia
  • asthma
  • anemia or hemoglobinopathies (genetic diseases of red blood cells, like sickle cell anemia)

Children under two years of age should not receive gadoversetamide injection because their developing kidneys may be at risk. The FDA classifies gadoversetamide injection as a Pregnancy Category C drug, meaning that it may pose harm to a fetus. Discuss with your doctor whether these risks outweigh the possible benefits of gadoversetamide injection. Women who are breastfeeding should stop for 72 hours after the injection. Do not keep any milk you express or pump during this time period.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.