What should I know before taking an SGLT2 inhibitor?

Dr. Darria Long Gillespie, MD
Emergency Medicine
Your doctor will need to test your kidney function before starting treatment. If you have severe kidney impairment or end-stage renal disease (ESRD), you should not take an SGLT2 inhibitor.

If you have severe liver impairment, you should not take canagliflozin. Other SGLT2 inhibitors may also not be good options for you.

If you have bladder cancer, you should not take dapagliflozin. If you have had bladder cancer in the past, dapagliflozin may not be a good option for you.

If you are pregnant, planning to become pregnant, or may be pregnant, SGLT2 inhibitors may not be good options for you. It is not known if they are safe for pregnant women.

You should not take an SGLT2 inhibitor if you are breastfeeding. 

​​​​​​This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor. 

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Diabetes mellitus (MEL-ih-tus), often referred to as diabetes, is characterized by high blood glucose (sugar) levels that result from the body’s inability to produce enough insulin and/or effectively utilize the insulin. Diabetes ...

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.