How does Jardiance (empagliflozin) work?

Jardiance (empagliflozin) lowers your HbA1c and blood glucose in a very interesting way – extra glucose leaves your body when you pee (or urinate). 

The body is very good at soaking up any blood sugar in the urine back into your bloodstream. A protein located in the kidney called SGLT-2 (sodium glucose transporter) helps do this.  

Jardiance is a type of drug called a SGLT-2 inhibitor. That means it blocks this protein, so glucose leaves your body through the urine, lowering your blood glucose level.  The amount of glucose that is removed from the body into the urine with Jardiance treatment is about equal to 40-50 sugar cubes a day.

Continue Learning about Diabetes


Diabetes mellitus (MEL-ih-tus), often referred to as diabetes, is characterized by high blood glucose (sugar) levels that result from the body’s inability to produce enough insulin and/or effectively utilize the insulin. Diabetes ...

is a serious, life-long condition and the sixth leading cause of death in the United States. Diabetes is a disorder of metabolism (the body's way of digesting food and converting it into energy). There are three forms of diabetes. Type 1 diabetes is an autoimmune disease that accounts for five- to 10-percent of all diagnosed cases of diabetes. Type 2 diabetes may account for 90- to 95-percent of all diagnosed cases. The third type of diabetes occurs in pregnancy and is referred to as gestational diabetes. Left untreated, gestational diabetes can cause health issues for pregnant women and their babies. People with diabetes can take preventive steps to control this disease and decrease the risk of further complications.

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.