What are common side effects of pimecrolimus?

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Headaches and a runny nose are especially common effects of pimecrolimus. You may feel burning or stinging at the areas where you applied the pimecrolimus; this usually improves within several days. Other side effects that occur frequently include cough, flu-like symptoms and fevers. Because pimecrolimus weakens your immune system, you are at risk of infections caused by viruses, such as influenza.