Do topical calcineurin inhibitors have side effects?

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Dr. Darria Long Gillespie, MD
Emergency Medicine
Side effects may include flu-like symptoms, headaches, itching, and redness or a burning sensation of the skin. Topical calcineurin inhibitors increase the risk of viral, bacterial, fungal, and protozoal infections, including opportunistic infections. Some people have developed lymphoma or skin cancer. 

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