How does Cortisporin ointment interact with other medications?

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Some medications might react poorly with Cortisporin ointment and should be avoided or used with caution in combination with it. In particular, chemotherapy treatments, vitamins and other creams or ointments might interact poorly with Cortisporin ointment. Also, consult with your doctor before getting any vaccines while using Cortisporin ointment, as the vaccine might not work properly. However, since so little of the ointment is absorbed into the bloodstream, its interaction with other drugs is minimal. Still, it is a good idea to tell your doctor about all medicines, supplements, vitamins and herbal remedies that you take before using Cortisporin ointment.