What are the side effects of topical urea used for skin care?

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Topical urea may cause side effects in some people. In rare cases, severe allergic reaction can occur, leading to symptoms like swelling of the mouth, face, lips or tongue; chest tightness; difficulty breathing; and hives. Call 911 for emergency help if any of these symptoms occur. In addition, severe or long-lasting irritation or redness can occur on the skin where the product is applied. More commonly, topical urea side effects are mild and temporary. These include: itching, stinging, burning or other mild irritation of the skin where urea is used. Talk to your doctor if you're concerned about any side effects that develop while using topical urea.