What are possible complications of collagen injections?

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Because some, not all, collagen is derived from cows, every now and then there’s a spate of Internet scare stories about the risk of getting hoof-and-mouth or mad cow disease (BSE) from bovine collagen injections. However, not only is there no real basis for this, but FDA regulations require that bovine collagen for injections come from countries that are free of mad cow disease.

Bovine collagen’s only true drawback is that it requires a month-long allergy testing process before it can be injected. Fortunately, there are now other types of collagen that contain natural human collagen—Cosmoderm and Cosmoplast—and as such, they don’t require allergy testing. These options are purified from dermal tissue grown under controlled laboratory conditions. Cosmoderm is typically used for fine lines such as crow’s feet and the fine lines above the lips while Cosmoplast is used in the treatment of deeper lines and furrows, and lip augmentation or plumping.

From The Mind-Beauty Connection: 9 Days to Less Stress, Gorgeous Skin, and a Whole New You by Amy Wechsler.