What is treatment-resistant depression?


Treatment-resistant depression is defined by failing to achieve full remission after three full trials of antidepressants, says Tarique Perera, MD, a psychiatrist with Contemporary Care of Connecticut. In this video, he explains.

Anthony Beck
Addiction Medicine
When several anti-depressant medications have been tried without success or enough success.
As its name suggests, treatment-resistant depression is depression that does not respond to traditional doses of antidepressants and psychotherapy ("talk therapy").

While currently available medications and psychotherapies are effective for many people with depression, unfortunately a substantial number of people do not respond. When depression is resistant to treatment, it can become chronic, lasting for long periods of time in some cases. Depression can also recur, making long-term maintenance strategies very important. Treatment-resistant depression sometimes responds to brain stimulation such as vagus nerve stimulation, transcranial magnetic stimulation, and electroconvulsive therapy.

Continue Learning about Depression Treatment

Depression Treatment

Depression Treatment

Because it is a multi-faceted condition, treatment for depression is multi-faceted as well. Minor depression can often be treated with therapy and a few simple lifestyle changes, while chronic or major depression treatment can req...

uire medication in addition to therapy. In some severe cases, electroconvulsive therapy (ECT) may be used. It's important to work with your mental health professional to determine which course of treatment for your type of depression is most appropriate.

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.