What is treatment-resistant depression?

While currently available medications and psychotherapies are effective for many people with depression, unfortunately a substantial number of people do not respond. When depression is resistant to treatment, it can become chronic, lasting for long periods of time in some cases. Depression can also recur, making long-term maintenance strategies very important. Treatment-resistant depression sometimes responds to brain stimulation such as vagus nerve stimulation, transcranial magnetic stimulation, and electroconvulsive therapy.

As its name suggests, treatment-resistant depression is depression that does not respond to traditional doses of antidepressants and psychotherapy ("talk therapy").
Anthony Beck
Addiction Medicine
When several anti-depressant medications have been tried without success or enough success.

Treatment-resistant depression is defined by failing to achieve full remission after three full trials of antidepressants, says Tarique Perera, MD, a psychiatrist with Contemporary Care of Connecticut. In this video, he explains.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.