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How are the two main types of cutaneous T-cell lymphoma related?

Mycosis fungoides and Sezary syndrome are by far the two most common types of cutaneous T-cell lymphoma. Although they are usually classified as distinctly different tumors, these tumors are sometimes related. Most people with Sezary syndrome develop the disease without any preceding disorder, but in some individuals, the Sezary syndrome has developed as a progression of mycosis fungoides. Likewise, most individuals with mycosis fungoides never progress beyond the early stage, but approximately 10 percent will have a more aggressive form, and some of these people will develop Sezary syndrome. It is not known why some mycosis fungoides tumors progress to Sezary syndrome, while the vast majority does not. Some authorities consider Sezary syndrome to be a variant of mycosis fungoides.

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