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What medications interact with the progestin-only pill?

Donna Hill Howes, RN
Family Practitioner

If you are taking dabrafenib, enzalutamide, tranexamic acid, or ulipristal, progestin-only pills can lead to side effects and should be avoided.

The following medications can cause hormonal birth control methods, including the progestin-only pill, to fail:

  • aprepitant
  • barbiturates
  • bexarotene
  • bosentan
  • carbamazepine
  • efavirenz
  • felbamate
  • fosphenytoin
  • griseofulvin
  • lamotrigine
  • mifepristone
  • mycophenolate
  • nevirapine
  • oxcarbazepine
  • perampanel
  • phenytoin
  • primidone
  • protease inhibitors
  • acitretin
  • topiramate

If you take progestin-only pills, you should not take St. John's wort or sweet wormwood (artemether). 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.