What medications interact with the progestin-only pill?

Donna Hill Howes, RN
Family Practitioner

If you are taking dabrafenib, enzalutamide, tranexamic acid, or ulipristal, progestin-only pills can lead to side effects and should be avoided.

The following medications can cause hormonal birth control methods, including the progestin-only pill, to fail:

  • aprepitant
  • barbiturates
  • bexarotene
  • bosentan
  • carbamazepine
  • efavirenz
  • felbamate
  • fosphenytoin
  • griseofulvin
  • lamotrigine
  • mifepristone
  • mycophenolate
  • nevirapine
  • oxcarbazepine
  • perampanel
  • phenytoin
  • primidone
  • protease inhibitors
  • acitretin
  • topiramate

If you take progestin-only pills, you should not take St. John's wort or sweet wormwood (artemether). 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor. 

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