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Do any drugs interact with medroxyprogesterone injections?

Donna Hill Howes, RN
Family Practitioner

The following drugs may cause hormonal birth control methods (including medroxyprogesterone injections) to fail:

  • anticonvulsants
  • griseofulvin
  • antiretroviral drugs
  • aprepitant
  • barbiturates
  • bosentandabrafenib
  • mifepristone
  • mycophenolate
  • rifamycins
  • systemic retinoids
  • tranexamic acid

If you are taking an anticoagulant, medroxyprogesterone can lead to side effects and should be avoided.

If you are taking ulipristal, medroxyprogesterone can lead to side effects and should be avoided.

If you take medroxyprogesterone, you should avoid St. John's wort and sweet wormwood, also called artemether.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.