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One of the most common side effects of isosorbide dinitrate is headaches. Do not stop taking this drug if a headache occurs; a headache is a sign that isosorbide dinitrate is working. Headaches usually develop after first taking isosorbide dinitrate and subside after a couple of weeks. You may treat a mild headache with acetaminophen or aspirin. Talk to your doctor if these headaches are severe or persist after an extended period of time.
Isosorbide dinitrate dilates blood vessels and is used to treat heart disease. It also dilates the blood vessels inside the headache which can cause a headache. This usually happens when a patient first starts using isosorbide and goes away with time. Isosorbide is an important medication so it should not be stopped without discussion with your physician.
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