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What Are PD-1 and PD-L1?

Learn how these proteins help people with cancer and their healthcare providers make treatment decisions.

What Are PD-1 and PD-L1?

Biomarker testing looks for the presence of certain biological molecules on cancer cells. When certain biomarkers are present in certain levels, it gives healthcare providers an idea of the processes the cancer is using to grow and spread—and predict what therapies might be most effective in treating that cancer. Certain anti-cancer treatments work by disrupting these processes.

PD-1 and PD-L1 proteins are one example of biomarkers that are found in some cancers. Here we look at the role of these proteins in the body, how cancer cells use these proteins to fuel their growth, and how certain anti-cancer drugs target these proteins.

Immune checkpoint inhibitors
The immune system attacks and destroys cells, pathogens, and foreign substances that enter the body. To keep the immune system from damaging healthy cells, the body also contains proteins called immune checkpoints.

PD-1 and PD-L1 are immune checkpoint inhibitors. Together, they form what is called the PD-1/PD-L1 pathway.

  1. PD-1 is a protein found on immune cells called T cells.
  2. PD-L1 is a protein found on normal healthy cells.
  3. When PD-1 binds to PD-L1, it stops the immune system from attacking the normal healthy cells.

Keep in mind that this is a simplified explanation of a complex biological process.

PD-L1 on cancer cells
Some cancer cells produce high amounts of PD-L1. These high levels of PD-L1 essentially act as a disguise, letting the cancerous cells appear normal and avoid attack when they encounter T cells. This allows the cancerous cells to continue to grow and proliferate.

PD-1/PD-L1 inhibitors
Some anti-cancer drugs work by disrupting the PD-1/PD-L1 pathway. These drugs are called PD-1 inhibitors or PD-L1 inhibitors, depending on which protein they act on. When this immune checkpoint process is disrupted, T cells will attack the cancer cells.

PD-1 and PD-L1 inhibitors are categorized as immunotherapies—cancer treatments that work by helping the body’s immune system fight cancer. These drugs may be prescribed alone, or in combination with other cancer therapies, such as chemotherapy.

Your healthcare providers may order tests to measure the levels of PD-L1. This test involves taking a biopsy of the cancer cells, which are then examined in a lab. PD-L1 levels are one piece of information that your healthcare providers will use to help predict what cancer treatments may be effective.

Remember that every case of cancer is different, and the best source of information about your diagnosis is your healthcare team.

Medically reviewed in December 2020.

Sources:
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UpToDate. "Management of advanced non-small cell lung cancer lacking a driver mutation: Immunotherapy."
So Yeon Kim and Balazs Halmos. "Choosing the best first-line therapy: NSCLC with no actionable oncogenic driver." Lung Cancer Management, 2020. Vol. 9, No. 3.
NCI Dictionaries. "Biomarker."
NCI Dictionaries. "PD-1."
Andrea Bianco, Umberto Malapelle, et al. "Targeting immune checkpoints in non small cell lung cancer." Current Opinion in Pharmacology, 2018. Vol. 40.
Philip T. Cagle, Ross A. Miller, and Timothy Craig Allen. "Nonneuroendocrine Carcinomas (Excluding Sarcomatoid Carcinoma) and Salivary Gland Analogue Tumors of the Lung." Practical Pulmonary Pathology: A Diagnostic Approach. Third Edition, 2018.
Yanyan Han, Dandan Liu, and Lianhong Li. "PD-1/PD-L1 pathway: current researches in cancer." American Journal of Cancer Research, 2020. Vol. 10, No. 3.
NCI Dictionaries. "T cell."
American Cancer Society. "Immune Checkpoint Inhibitors and Their Side Effects."
Konrad Pawelczyk, Aleksandra Piotrowska, et al. "Role of PD-L1 Expression in Non-Small Cell Lung Cancer and Their Prognostic Significance according to Clinicopathological Factors and Diagnostic Markers." International Journal of Molecular Sciences, 2019. Vol. 20, No. 4.
Taher Abu Hejleh, Muhammad Furqan, Zuhair Ballas and Gerald Clamon. "The clinical significance of soluble PD-1 and PD-L1 in lung cancer." Critical Reviews in Oncology and Hematology, 2019. Vol. 143.
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