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What are the side effects of bupropion?

Donna Hill Howes, RN
Family Practitioner

Side effects may include sweating, flushing, dizziness, headaches, blurred vision, ringing in the ears, nosebleeds, dry mouth, swallowing problems, mouth ulcers, heart palpitations, blood pressure changes, chest pain, and appetite or weight change. Other side effects may include abdominal pain, vomiting, diarrhea, constipation, itching, rash, muscle or joint pain, loss of sex drive, problems urinating, loss of memory or concentration, drowsiness, and strange dreams.

The FDA recommends watching all people treated with antidepressants closely for signs that symptoms are getting worse, suicidal thoughts or actions, and unusual behavior changes. They should be watched closely in the first few months of treatment and when the dose is changed. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor. 

Dr. Frank T. Leone, MD
Pulmonary Disease Specialist

Bupropion helps reduce the cravings that you may experience when you quit smoking. However, it may cause some side effects. These include:

  • Difficulty sleeping
  • Vivid dreams
  • Dry mouth
  • Agitation

If you have trouble sleeping, try taking a second pill earlier in the evening, i.e., after dinner. Dry mouth and agitation usually go away after a few days.

Donna Hill Howes, RN
Family Practitioner

During the first few weeks of taking bupropion, you may have dry mouth and some trouble sleeping, but both usually go away. Blood pressure can go up, so get it monitored. Some people notice nausea, dizziness, and headache. If any side effects are severe, call your doc. There's a small risk of a seizure while taking bupropion—only 1 in 1,000—but it can occur. There's also a small risk of increased libido.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.