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Can I change from aromatase inhibitors to tamoxifen if I have side effects?

Sara Hurvitz, MD
Hematology & Oncology
Aromatase inhibitors are a little bit better in treating breast cancer than tamoxifen, so the standard of care is to start with them. They’re a little better at preventing breast cancer recurrence; to date, there’s no significant difference in overall survival. The side effects are different, but some women tolerate tamoxifen better than aromatase inhibitors. Tamoxifen an appropriate option for a woman who has tried the aromatase inhibitors and has experienced too many side effects such as joint pain and stiffness and worsening of osteoporosis.

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