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How do medications treat typhoid fever?

Antibiotics are the only medications used to treat typhoid fever. Most of these antibiotics are taken by mouth and then work within the body to kill the bacteria that cause the infection. One antibiotic that was formerly used for typhoid fever was chloramphenicol, but concern about its side effects and about resistance developing in the bacteria that cause the disease has made it less common. Usually ampicillin, trimethoprim-sulfamethoxazole, or ciprofloxacin are prescribed. Make sure to take the entire course of antibiotics, even if you feel well. Patients who are comatose, in shock, or are delirious as a result of typhoid fever may be treated with corticosteroids in addition to the antibiotics.

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