Advertisement

How effective is epilepsy surgery in kids with tuberous sclerosis (TSC)?

Dr. Aria Fallah, MD
Neurosurgeon

A good seizure outcome can be achieved in about 70 percent of children with tuberous sclerosis complex (TSC) who undergo surgery for epilepsy. That means either a class one outcome, which means free of all seizures, or a class two outcome, which means rare seizures or only once in a while.

At about one year out, close to 60 percent have seizure freedom. But the longer these children are followed, the higher the likelihood of them having recurrent seizures. Over time, the longer children go without having a seizure occurrence after a surgery, the more likely they'll never have seizures again.

Seizures around the time of surgery can be common. Just because a child has one doesn't mean the surgery failed. It takes several months, usually at least a year, before doctors can tell how successful the surgery was.

Children that have had larger resections, more than just the tuber itself, have done much better than the children that have had a tuberectomy only. So, there's a higher chance of having recurrent seizures when children have had the tuberectomy-only procedure. That means that the tuber itself may not be what's causing the epilepsy. It actually may be that tissues surrounding the tuber and commonly, there's cortical dysplasia around the tuber, could be the cause of the epilepsy.

Mild or no developmental delays, or the less developmental delay the child has, the more likely it can result in a good outcome. Lastly, if the electroencephalogram (EEG) and magnetic resonance imaging (MRI) correspond with the same area, or the more the tests all pointing to the same area of the brain, the more confidently doctors can say that removing that area of the brain can result in seizure freedom.

Continue Learning about Autosomal Dominant Genetic Disorders

What kind of surgery can treat epilepsy in kids with tuberous sclerosis?
Dr. Aria Fallah, MDDr. Aria Fallah, MD
The two main kinds of surgery that are performed to treat epilepsy in children with tuberous scleros...
More Answers
When is epilepsy surgery a good option for kids with tuberous sclerosis?
Dr. Aria Fallah, MDDr. Aria Fallah, MD
Epilepsy surgery can be a good option for kids with tuberous sclerosis (TSC) when two medications ha...
More Answers
For people with tuberous sclerosis, why does the whole tuber need removal?
Dr. Aria Fallah, MDDr. Aria Fallah, MD
For people with tuberous sclerosis (TSC), the whole tuber needs to be removed because incomplete res...
More Answers
What is laser treatment for epilepsy in kids with tuberous sclerosis (TSC)?
Dr. Aria Fallah, MDDr. Aria Fallah, MD
With laser treatment for epilepsy in children with tuberous sclerosis complex (TSC), instead of doin...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.