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MediGuard answeredSpiriva is to be used once per day at the same time each day and Foradil is to be used at the most every 12 hours, and no closer together than that. The time of day should not matter. The Proventil is a rescue inhaler that should be used when you are feeling short of breath, unless it has been prescribed otherwise by your physician. If your physician has prescribed the Proventil to be used on a scheduled basis, you should use it about 15 minutes prior to the Foradil and the Spiriva. Only use Proventil regularly if it is prescribed that way.