Aspirin and ibuprofen are nonsteroidal anti-inflammatory drugs, or NSAIDs. These drugs can be quite effective when treating conditions that cause inflammation, but fibromyalgia doesn't cause any inflammation. As a result, NSAIDs aren't very effective at treating the condition. However, in some cases, they can be effective when used in combination with other medications. Talk to your doctor about what medications you should be taking to treat your fibromyalgia.